The aim of this study is to review the diagnostic and monitoring performances of MRI and PET/CT in assessing diabetic foot complications, such as diabetic foot osteomyelitis (DFO) and Charcot neuro-osteoarthropathy
(CN). Moreover, the goal is to identify the use of Near Infrared Radiation (NIR) as a clinical translation for screening and monitoring complications with no radiation exposure. Almost all the published materials
included in this study were searched in the Scopus database and limited from the year 2000 to 2018 which resulted in 277 papers. Only 47 were utilized. In comparison, modalities have their own clinical strengths and
limitations in terms of sensitivity and specificity, demonstration of anatomical details, confirmation of diagnosis and extent of infection, and radiation exposure. Also, NIR as an emerging tool could be a modality of choice in measuring blood glucose concentration within the body.