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Development of a Magnetic-field Stimulation System for Cell Cultures in situ: Simulation by Finite Element Analysis
Journal of Magnetics, Volume 22, Number 2, 30 Jun 2017, Pages 326-332
Abstract
The effects of exposure to an extremely low-frequency magnetic field (25 Hz 20G) on animal cells have been studied. In some reports, stimulation was performed for fixed frequency and variations in magnitude; however, animal-cell experiments have established that both parameters play an important role. The present work undertook the modeling, simulation, and development of a uniform-magnetic-field generation system with variable frequency and stimulation intensity (0-60 Hz, 1-25G) for experimentation with cell cultures in situ. The results showed a coefficient of variation less than 1% of the magnetic-field dispersion at the working volume, which is consistent with the corresponding simulation results demonstrating a uniform magnetic field. On the other hand, long-term tests during the characterization process indicated that increments of only 0.4°C in the working volume temperature will not be an interfering factor when experiments are carried out in in situ cell cultures.
Keywords: magnetic field; extremely low frequency; helmholtz coils; hall effect; pulsed magnetic field
DOI: https://doi.org/10.4283/JMAG.2017.22.2.326
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