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No.3(pp.101-136)

Home > Issues > Volume 14 (2009) > No.3(pp.101-136)

Preparation of Chitosan-coated Magnetite Nanoparticles by Sonochemical Method for MRI Contrast Agent

Journal of Magnetics, Volume 14, Number 3, 30 Sep 2009, Pages 124-128

Jun Hee Cho(Quantum Optics Division, Korea Atomic Energy Research Institute), Sang Gil Ko(Environment & Resources Research Center, Korea Research Institute of Chemical Technology), Yangkyu Ahn*

(Department of Chemistry, Konyang University), Eun Jung Choi(Department of Opthalmic Optics, Konyang University)

Abstract

Magnetic nanoparticles were synthesized by using the sonochemical method with oleic acid as a surfactant. The average size of the magnetite nanoparticles was controlled by varying the ratio R=[H₂O]/[surfactant] in the range of 2 to 9 nm. To prepare chitosan-coated magnetite nanoparticles, chitosan solution was added to a magnetite colloid suspension under ultrasonication at room temperature for 20 min. The chitosan-coated magnetite nanoparticles were characterized by several techniques. Atomic force microscopy (AFM) was used to image the chitosan-coated nanoparticles. Magnetic hysteresis measurement was performed by using a superconducting quantum interference device (SQUID) magnetometer to investigate the magnetic properties of the magnetite nanoparticles and the chitosan-coated magnetite nanoparticles. The SQUID measurements revealed the superparamagnetism of both nanoparticles. The T1- and T2-weighted MR images of these chitosan-coated magnetite colloidal suspensions were obtained with a 4.7 T magnetic resonance imaging (MRI) system. The chitosancoated magnetite colloidal suspensions exhibited enhanced MRI contrasts in vitro.

Keywords: magnetite; sonochemical method; chitosan; MRI contrast agent

DOI: 10.4283/JMAG.2009.14.3.124

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